Diagnostic value of CA125, HE4 and Copenhagen Index in differentiating benign from malignant epithelial ovarian tumors

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 37; no. 5; pp. 628 - 632
• Main Authors: Gong, Shi-Peng, Chen, Yong-Ning, Zhang, Ya-di, Yao, Wei, Chen, Li, Liu, Shi-San, Wu, Huan
• Format: Journal Article
• Language: Chinese
• Published: China 20.05.2017
• Subjects: Biomarkers, Tumor - analysis; CA-125 Antigen - analysis; Diagnosis, Differential; Female; Humans; Neoplasms - diagnosis; Neoplasms, Glandular and Epithelial - diagnosis; Ovarian Neoplasms - diagnosis; Proteins - analysis; WAP Four-Disulfide Core Domain Protein 2
• ISSN: 1673-4254

To analyze diagnostic value of Copenhagen Index based on pretreatment serum CA125, HE4 and age in differentiating benign and malignant epithelial ovarian tumors. The clinical data were analyzed for 208 consecutive patients with epithelial ovarian tumors (including 100 with malignant and 108 with benign tumors) treated in our department between September, 2014 and September, 2016. The receiver-operating characteristic curve was drawn based on the golden standard of pathological diagnosis for calculation of the diagnostic sensitivity and specificity of CA125, HE4 and the Copenhagen Index. In the overall cases, early stage cases and advanced stage cases, the prediction probabilities of CA125, HE4 and Copenhagen Index were all significantly higher for malignant than in benign tumors (P<0.001). The sensitivities of CA125, HE4, Copenhagen Index for differentiating benign and malignant tumors were 81.0%, 86.0% and 91.0% in the overall cases, 64.0%, 68.0% and 72.0% in early stage cases, and 86.7%, 92.0% and 97.3% in