Correlation of serum eosinophil cationic protein with the severity of allergic rhinitis in childhood

• Published in: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Vol. 47; no. 8; p. 628
• Main Authors: Zhu, Xin-jie, Lu, Mei-ping, Chen, Ruo-xi, Zhu, Lu-ping, Qi, Qin-hong, Yin, Min, Cheng, Lei
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2012
• Subjects: Adolescent; Animals; Child; Child, Preschool; Eosinophil Cationic Protein - blood; Female; Humans; Immunoglobulin E - blood; Male; Pyroglyphidae - immunology; Retrospective Studies; Rhinitis, Allergic; Rhinitis, Allergic, Perennial - blood; Rhinitis, Allergic, Perennial - immunology
• ISSN: 1673-0860

To investigate the relationships between the severity of childhood allergic rhinitis (AR) and the peripheral blood eosinophil count, serum eosinophil cationic protein (ECP), total IgE (tIgE), and allergen-specific IgE (sIgE) levels. A total of 138 children with AR aged 3 to 17 (9.96 ± 3.78, x() ± s) years old were enrolled in the study. All children had persistent AR sensitized to house dust mites with a clinical history of 3 months to 12 (4.21 ± 2.72) years. The disease severity was evaluated using 10 cm-visual analogue scale (VAS), and the serum levels of ECP, tIgE and sIgE were determined using an ImmunoCAP system. Statistical analysis was conducted with SPSS11.0 software. Among 138 children with AR, the VAS scores for global severity of rhinitis and nasal obstruction symptom were 5.32 ± 2.16 and 4.78 ± 2.45, respectively. Blood eosinophil count was 0.39 [0.24; 0.63] (M[P(25); P(75)]) ×10(9)/ml. Serum levels of ECP and total IgE were 10.60 [3.26; 30.80] µg/L and (2.50 ± 0.53) log kU/L, respectively. Serum