Updated cytokine therapy of erectile dysfunction

Four types of cytokines are found to be related to the pathogenesis and treatment of ED. The cytokines capable of promoting angiogenesis can improve vascular endothelial function, promote endothelial regeneration and thus improve erectile function, those capable of promoting nerve regeneration can i...

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Bibliographic Details
Published inZhonghua nan ke xue Vol. 25; no. 7; p. 660
Main Authors Ti, Yun-Rong, Xiao, Dong-Dong, Lu, Mu-Jun
Format Journal Article
LanguageChinese
Published China 01.07.2019
Subjects
Animals
Cytokines - therapeutic use
Disease Models, Animal
Erectile Dysfunction - therapy
Humans
Male
Penile Erection
Penis - physiopathology
Rats
cytokine
outcome
erectile dysfunction
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Summary:Four types of cytokines are found to be related to the pathogenesis and treatment of ED. The cytokines capable of promoting angiogenesis can improve vascular endothelial function, promote endothelial regeneration and thus improve erectile function, those capable of promoting nerve regeneration can improve erectile function by protecting cavernous nerves, those capable of protecting the smooth muscle function can improve erectile function by promoting the smooth muscle expression and inhibiting penile fibrosis, and those inflammation-related cytokines can induce penile erection by acting on the corresponding receptor relaxing smooth muscle. Compared with PDE-5 inhibitors, cytokines are more targeted for the treatment of ED. However, current studies are mostly dependent on rat models and lack of large sample sizes, which has restricted further clinical application of cytokines. Although VEGF, IGF-1, BDNF and NGF can significantly improve the erectile function of ED rats, experiments with larger samples and larg
ISSN:1009-3591