Long-term efficacy of sublingual immunotherapy with Dermatophagoides Farianae Drops in children with allergic asthma sensitized to dust mites

• Published in: Zhonghua er ke za zhi Vol. 51; no. 10; p. 741
• Main Authors: Tian, Man, Lu, Yue-qian, Wang, Yu, Jiang, Yan-he, Zhao, De-yu
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2013
• Subjects: Administration, Sublingual; Adolescent; Animals; Anti-Asthmatic Agents - therapeutic use; Antigens, Dermatophagoides - administration & dosage; Antigens, Dermatophagoides - immunology; Asthma - drug therapy; Asthma - immunology; Asthma - therapy; Case-Control Studies; Child; Female; Follow-Up Studies; Humans; Male; Pyroglyphidae - immunology; Retrospective Studies; Sublingual Immunotherapy; Treatment Outcome
• ISSN: 0578-1310

To observe the efficacy of sublingual immunotherapy (SLIT) in children with allergic asthma during the treatment and 1 year after the treatment. This is an open and retrospective study; 80 children with mild-moderate allergic asthma between 4 and 14 years of age were chosen from the Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated to Nanjing Medical University from May to August, 2009. All children were sensitized to Dermatophagoides Farianae and/or Dermatophagoides Pteronyssinus and have received anti-asthma drug therapy for 3 months (baseline). Thirty-nine children in SLIT group underwent 2-year SLIT and combined with anti-asthma drug, these children were then followed up for 1 year. Forty-one children in drug group only received anti-asthma drug and were followed up for 3 years. The scores of asthma symptom, scores of asthma medication and the number of discontinuation of anti-asthma drug were compared between the SLIT group and drug group for the baseline, end of the 2nd year and