Expression Level of FLRG in Colon Cancer Tissue and Its Clinical Significance

To investigate the expression of follistatin related gene ( ) in colon cancer and its relationship with clinicopathological features of colon cancer. The cancer tissue, paracancerous tissue and normal tissue were collected from 80 patients with colon cancer who underwent radical operation from Decem...

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Published inSichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 51; no. 3; p. 361
Main Authors He, Xue-Lai, Xiong, Hai-Bo, Hou, Neng-Yi, Luo, Ren-Jie, Yu, Song, Hu, Xue-Mei, Xu, Jie, Pang, Ming-Hui
Format Journal Article
LanguageChinese
Published China 01.05.2020
Subjects
Colonic Neoplasms - genetics
Follistatin-Related Proteins
Humans
Immunohistochemistry
RNA, Messenger
Up-Regulation
Clinicopathological features
Colon cancer
FLRG
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Summary:To investigate the expression of follistatin related gene ( ) in colon cancer and its relationship with clinicopathological features of colon cancer. The cancer tissue, paracancerous tissue and normal tissue were collected from 80 patients with colon cancer who underwent radical operation from December 2018 to December 2019. Immunohistochemistry and Real-time PCR were carried out to examine the expression of FLRG and the clinical implications of FLRG was further analyzed. The expression of FLRG in colon cancer tissues was significantly higher than that in paracancerous tissues and normal tissues ( <0.05), and the expression of FLRG in paracancerous tissues was significantly higher than that in normal tissues ( <0.05). There was no significant difference in the expression of FLRG among colon cancer patients with different sex, age, tumor growth location and differentiation degree ( >0.05). The expression level of FLRG in patients with distant metastasis was higher than that in patients without distant metastas
ISSN:1672-173X
DOI:10.12182/20200560104