Bionic design, preparation and clinical translation of oral hard tissue restorative materials

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 56; no. 1; pp. 4 - 8
• Main Authors: Zhao, Han, Wei, Yan, Zhang, Xuehui, Yang, Xiaoping, Cai, Qing, Ning, Chengyun, Xu, Mingming, Liu, Wenwen, Huang, Ying, He, Ying, Guo, Yaru, Jiang, Shengjie, Bai, Yunyang, Wu, Yujia, Guo, Yusi, Zheng, Xiaona, Li, Wenjing, Deng, Xuliang
• Format: Journal Article
• Language: Chinese
• Published: China 18.02.2024
• Subjects: Bionics; Humans; Biomechanics; Bone filling materials; Guided bone regeneration membranes; Dental restoration materials; Electrical microenvironment
• ISSN: 1671-167X
• DOI: 10.19723/j.issn.1671-167X.2024.01.002

Oral diseases concern almost every individual and are a serious health risk to the population. The restorative treatment of tooth and jaw defects is an important means to achieve oral function and support the appearance of the contour. Based on the principle of "learning from the nature", Deng Xuliang's group of Peking University School and Hospital of Stomatology has proposed a new concept of "microstructural biomimetic design and tissue adaptation of tooth/jaw materials" to address the worldwide problems of difficulty in treating dentine hypersensitivity, poor prognosis of restoration of tooth defects, and vertical bone augmentation of alveolar bone after tooth loss. The group has broken through the bottleneck of multi-stage biomimetic technology from the design of microscopic features to the enhancement of macroscopic effects, and invented key technologies such as crystalline/amorphous multi-level assembly, ion-transportation blocking, and multi-physical properties of the micro-environment reconstruction,