Relationship between intestinal mucosal inflammation and mental disorders in patients with irritable bowel syndrome
To examine the relationship between inflammation and the comorbidity of mental disorders with irritable bowel syndrome (IBS) by comparing intestinal mucosa inflammatory biomarkers in patients with and without mental disorders. A total of 43 consecutive IBS patients fulfilling the Rome III criteria a...
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Published in | Zhong hua yi xue za zhi Vol. 92; no. 32; p. 2247 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
28.08.2012
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Subjects | |
Online Access | Get more information |
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Summary: | To examine the relationship between inflammation and the comorbidity of mental disorders with irritable bowel syndrome (IBS) by comparing intestinal mucosa inflammatory biomarkers in patients with and without mental disorders.
A total of 43 consecutive IBS patients fulfilling the Rome III criteria and 15 volunteers serving as controls without digestive symptoms were recruited and interviewed with Composite International Diagnostic Interview (CIDI) by the well-trained staff and thus classified as with or without mental disorders. All subjects underwent colonoscopy and biopsies were acquired from the mucosa of distal ileum and colon. CD3(+) lymphocytes, mast cells, 5-HT positive cells and (indoleamine 2,3-dioxygenase) IDO positive cells were identified immunohistologically in mucosa biopsies in volunteers (n = 13), IBS patients without mental disorder (n = 24) and IBS patients with mental disorder (n = 19).
The incidence of mental disorders in IBS patients was significantly higher than that in the volunteers (1 |
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ISSN: | 0376-2491 |
DOI: | 10.3760/cma.j.issn.0376-2491.2012.32.006 |