Application of biomimetic mineralized collagen bone graft material in rabbits posterolateral spinal fusion

• Published in: Zhongguo xiu fu chong jian wai ke za zhi Vol. 32; no. 9; pp. 1137 - 1143
• Main Authors: Song, Tianxi, Hu, Yanli, Cui, Yun, He, Zhimin, Zhu, Jinliang, Wang, Xiumei, Qiu, Zhiye
• Format: Journal Article
• Language: Chinese
• Published: China 15.09.2018
• Subjects: Animals; Biomimetics; Bone Substitutes; Bone Transplantation; Calcification, Physiologic; Collagen; Male; Osteogenesis; Rabbits; Spinal Fusion; Spine; osteoinductivity; spine fusion; bone marrow; rabbit; Mineralized collagen
• ISSN: 1002-1892
• DOI: 10.7507/1002-1892.201804119

To investigate the bone repair and regeneration ability of biomimetic mineralized collagen bone graft material and autologous bone marrow in rabbit posterolateral spinal fusion model. Twenty-seven 20-week-old male New Zealand white rabbits ［weighing (5.0±0.5) kg］ were used to establish the posterolateral spinal fusion model of L and L segments by stripping the transverse process and exposing cancellous bone with electric burr. The rabbits were randomly divided into 3 groups, 9 in each group. Groups A, B, and C were implanted 1.5 mL autologous iliac bone, 1.5 mL (30 mm×10 mm×5 mm) biomimetic mineralized collagen bone graft material, and 1.5 mL (30 mm×10 mm×5 mm) biomimetic mineralized collagen bone graft material and autologous bone marrow in each bone defect. At 4, 8, and 12 weeks after operation, the apparent hardness of the bone grafting area was observed by manipulation method, in order to evaluate bone graft fusion effects. Three animals were sacrificed in each group at each time point, the vertebral body