Analysis of cytomegaloviral antigenemia test and re-test after antiviral chemotherapy in patients with autoimmune and non-autoimmune diseases

• Published in: Zhong hua yi xue za zhi Vol. 92; no. 34; p. 2426
• Main Authors: Cui, Jing-tao, Ni, An-ping, Wu, Ye-li, Kong, Ling-jun, Yan, Wen-juan, Li, Qian, Dou, Ya-ling, Chen, Lan-lan
• Format: Journal Article
• Language: Chinese
• Published: China 11.09.2012
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Viral - blood; Antiviral Agents - therapeutic use; Autoimmune Diseases - blood; Autoimmune Diseases - complications; Autoimmune Diseases - drug therapy; Child; Child, Preschool; Cytomegalovirus; Cytomegalovirus Infections - blood; Cytomegalovirus Infections - complications; Cytomegalovirus Infections - drug therapy; Female; Humans; Infant; Male; Middle Aged; Retrospective Studies; Young Adult
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2012.34.013

To retrospectively analyze the cytomegalovirus (CMV) antigenemia test and re-test after antiviral chemotherapy in patients with autoimmune and non-autoimmune diseases. CMV Brite kit and indirect immunofluorescence were used to detect CMVpp65 antigenemia in 6471 peripheral blood leukocyte specimens from 5325 clinic and hospitalized patients with clinically suspicious CMV infections from May 2008 to February 2012. And the positive results were defined as episodes of systemic CMV activity. In 6471 EDTA-treated peripheral blood specimens, 948 (14.6%) were found with positive CMV antigenemia. The average positive rate from 13 kinds of autoimmune diseases was 34.9% (670/1922) in which systemic lupus erythematosus patients had the highest (52.4%, 551/1052). Meanwhile, the average positive rate from 12 kinds of non-autoimmune diseases was only 6.1% (144/2367) in which it was 17.3% (27/156) in patients with respiratory/acute renal failure, acquired immunodeficiency syndrome (AIDS) and kidney transplant recipients. And