Clinical features and prognostic factors of brain metastasis from colorectal cancer

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 38; no. 1; pp. 63 - 68
• Main Authors: Sun, Zengfeng, Sun, Yafang, Tan, Licai, He, Jia, Li, Xiaoxia, She, Chunhu, Li, Wenliang
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2016
• Subjects: Brain Neoplasms - mortality; Brain Neoplasms - secondary; Brain Neoplasms - therapy; Chemoradiotherapy; Colorectal Neoplasms; Humans; Liver Neoplasms - secondary; Lung Neoplasms - secondary; Neoplasm Staging; Prognosis; Rectal Neoplasms - pathology; Retrospective Studies; Survival Rate; Time Factors
• ISSN: 0253-3766
• DOI: 10.3760/cma.j.issn.0253-3766.2016.01.012

The aim of this study was to analyze the clinical features and prognostic factors in patients with brain metastasis from colorectal cancer (CRC). Clinical materials of 45 colorectal cancer patients who developed brain metastasis were collected, and the data and follow-up data of those patients were retrospectively analyzed. Most brain metastases were from rectal cancer (64.4%), and 80.0% of the 45 cases had extracranial metastases. The most common extracranial metastatic site was the lung (57.8%), followed by the liver (35.6%). All the brain metastases in patients with liver metastases were supratentorial, while in contrast, 44.8% of the patients without liver metastasis had subtentorial metastasis, showing a significant difference between them (P<0.05). The interval time from diagnosis of CRC to the development of brain metastases in case of Dukes D stage was 12.0 months, significantly shorter than that in the cases of Dukes A stage (24.0 months), B (36.0 months) and C (29.0 months) (P<0.05). The interval ti