Inhibiting pyroptosis: novel immune evasion strategies for pathogens

Pyroptosis is a type of programmed cell death mediated by the Gasdermin family. It is triggered in response to pathogen infection or other danger signals. The activation of Gasdermins leads to pyroptosis and the release of large amounts of inflammatory cytokines. Pyroptosis plays a crucial role in c...

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Published inYíchuán Vol. 45; no. 11; p. 986
Main Authors Mao-Yi, Yang, Xiao-Yue, Cui, Shi-Qi, Zheng, Shi-Yao, Ma, Zeng-Zhang, Zheng, Wan-Yan, Deng
Format Journal Article
LanguageEnglish
Published China 20.11.2023
Subjects
Animals
Humans
Immune Evasion
Pyroptosis - immunology
pyroptosis
pathogen
effector protein
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Summary:Pyroptosis is a type of programmed cell death mediated by the Gasdermin family. It is triggered in response to pathogen infection or other danger signals. The activation of Gasdermins leads to pyroptosis and the release of large amounts of inflammatory cytokines. Pyroptosis plays a crucial role in combating pathogen infections, as it helps to eliminate infected cells and activate the immune system. However, pathogens have already developed sophisticated strategies to evade or inhibit pyroptosis, allowing them to persist and facilitate infection. This review provides an overview of the discovery of pyroptosis and its importance in anti-infectious immunity. We also discuss several new strategies for inhibiting pyroptosis by pathogens. A thorough learning of the occurrence and regulation of pyroptosis may reveal the pathogenesis of related infectious diseases and contribute to developing effective anti-infective therapeutic strategies.
ISSN:0253-9772
DOI:10.16288/j.yczz.23-191