Re and (99m)Tc complexes of BodP3--multi-modality imaging probes

A fluorescent tridentate phosphine, BodP3 (2), forms rhenium complexes which effectively image cancer cells. Related technetium analogues are also readily prepared and have potential as dual SPECT/fluorescent biological probes.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 98; pp. 15503 - 15505
Main Authors Davies, Laura H, Kasten, Benjamin B, Benny, Paul D, Arrowsmith, Rory L, Ge, Haobo, Pascu, Sofia I, Botchway, Stan W, Clegg, William, Harrington, Ross W, Higham, Lee J
Format Journal Article
LanguageEnglish
Published England 21.12.2014
Subjects
Cell Line, Tumor
Coordination Complexes - analysis
Crystallography, X-Ray
Fluorescent Dyes - analysis
Humans
Male
Models, Molecular
Multimodal Imaging
Optical Imaging
Phosphines - analysis
Prostatic Neoplasms - diagnosis
Rhenium - analysis
Technetium - analysis
Tomography, Emission-Computed, Single-Photon
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Summary:A fluorescent tridentate phosphine, BodP3 (2), forms rhenium complexes which effectively image cancer cells. Related technetium analogues are also readily prepared and have potential as dual SPECT/fluorescent biological probes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1364-548X
DOI:10.1039/c4cc06367h