Study on the immuno-effects and influencing factors of Chinese hamster ovary (CHO) cell hepatitis B vaccine among adults, under different dosages

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 31; no. 7; p. 767
• Main Authors: Zhang, Wei, Lin, Chang-ying, Han, Li-li, Li, Li-qiu, Gao, Pei, Lin, Hui, Gong, Xiao-hong, Huang, Fang, Tang, Ya-qing, Ma, Jian-xin, Zhang, Hai-yan, Wang, Chen, Yang, Peng, Li, Hui, Sun, Mei-ping, He, Xiong, Pang, Xing-huo
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2010
• Subjects: Adolescent; Adult; Animals; CHO Cells; Cricetinae; Cricetulus; Double-Blind Method; Female; Hepatitis Antibodies - blood; Hepatitis B - immunology; Hepatitis B - prevention & control; Hepatitis B Surface Antigens - immunology; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; Humans; Immunization, Secondary; Male; Middle Aged; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Young Adult
• ISSN: 0254-6450

To evaluate the immuno-effect and related influencing factors on 10 µg and 20 µg Chinese hamster ovary (CHO) cell hepatitis B vaccine, using the randomized double-blind controlled trials in adult population. A total of 642 adults aged 18 - 45 years old, non-vaccinated against hepatitis B, and negative on five blood indicators for hepatitis B, were selected as the study objects from four districts in Beijing. The study objects were randomly divided into two groups, and then accepted 10 µg and 20 µg recombinant CHO hepatitis B vaccination by 0 - 1 - 6 month schedule. Influencing factors were investigated by means of questionnaire. Blood samples were collected one month after the third dose of vaccination. Anti-HBs level was detected by Abott chemiluminescence detection method. For the anti-HBs negative person, fluorescent quantitative PCR method was used to find out if the person had been infected with HBV. Logistic regression analysis was used to find out the influencing factors of anti-HBs seroconversion on e