Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report

Acquired amegakaryocytic thrombocytopenia (AAT) is a rare disease characterized by severe thrombocytopenia due to selective reduction or absence of megakaryocytes in the bone marrow. More commonly, patients with AAT have additional hematologic abnormalities such as macrocytosis or dyserythropoiesis,...

Full description

Saved in:
Bibliographic Details
Published inTurkish journal of haematology Vol. 22; no. 4; pp. 205 - 208
Main Authors Erkurt, Mehmet Ali, Kaya, Emin, Baran, Murat, Yitmen, Ece, Şenel, Soner, Kuku, İrfan, Aydoğdu, İsmet
Format Journal Article
LanguageEnglish
Published Turkey 05.12.2005
Online AccessGet full text

Cover

More Information
Summary:Acquired amegakaryocytic thrombocytopenia (AAT) is a rare disease characterized by severe thrombocytopenia due to selective reduction or absence of megakaryocytes in the bone marrow. More commonly, patients with AAT have additional hematologic abnormalities such as macrocytosis or dyserythropoiesis, abnormalities which may predict progression to aplastic anemia or myelodysplasia. A 52-year-old female was admitted to hospital with mucosal and gingival bleeding. Megakaryocytes were not seen on the bone marrow aspiration and biopsy. AAT was diagnosed. Although she was treated with immunosuppressive therapy including prednisolone and cyclosporine, her disease progressed to myelodysplastic syndrome. She died at the third month of diagnosis because of cerebral bleeding.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1300-7777