Effects of acupuncture of "Zhongchong" (PC 9) and "Yongquan" (KI 1) on P300 of event-related potentials in rats with vascular dementia

• Published in: Zhēncì yánjiū Vol. 38; no. 4; p. 281
• Main Authors: Li, Fei, Cai, Rong-Lin, Wu, Sheng-Bing, Zhai, Liang, Gao, Kang
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2013
• Subjects: Acupuncture Points; Acupuncture Therapy; Animals; Dementia, Vascular - physiopathology; Dementia, Vascular - psychology; Dementia, Vascular - therapy; Event-Related Potentials, P300; Humans; Learning; Male; Memory; Rats; Rats, Wistar
• ISSN: 1000-0607

To observe the effect of electroacupuncture (EA) stimulation of "Zhongchong" (PC 9) and "Yongquan" (KI 1) on P 300 of event-related potentials (ERPs) in rats with vascular dementia. A total of 48 Wistar rats were randomly divided into sham group (n = 12), model group (n = 12), EA group (n = 12) and medication group (n = 12). Vascular dementia model was established by occlusion of the bilateral vertebral arteries and cervical arteries. EA (1-2 mA, 2 Hz/20 Hz) was applied to bilateral "Zhongchong" (PC 9) and "Yongquan" (KI 1) for 15 min, once daily for 28 days. Rats of the medication group were treated by intragastric perfusion of Nimodipine (12 mg/kg), twice daily for 28 days. The rats' learning-memory ability was detected by step-down passive and active avoidance tests, and P 300 of ERPs detected by Neuroscan Nuamps system. Compared with the sham group, the reaction time and error times of learning performance and error times of memory performance as well as P 300 latency in the model group were significantly