Learning and Memory Capacity and NMDA Receptor Expression in Shen Deficiency Constitution Rats

To explore material bases and neurobiological mechanisms of "Shen storing will" by observing learning and memory capacities and N-methyl-D-aspartic acid (NMDA) receptor expressions in Shen deficiency constitution (SDC) rats. Totally 40 SD rats were randomly divided into the model group, th...

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Published inZhongguo Zhong xi yi jie he za zhi Vol. 36; no. 5; p. 597
Main Authors Sun, Yu-ru, Sun, Yao-guang, Zhang, Qi, Wang, Xiao-di, Wang, Xing, Sun, Li-jun
Format Journal Article
LanguageChinese
Published China 01.05.2016
Subjects
Animals
Drugs, Chinese Herbal - pharmacology
Female
Learning - drug effects
Memory - drug effects
Pregnancy
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - metabolism
Up-Regulation
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Summary:To explore material bases and neurobiological mechanisms of "Shen storing will" by observing learning and memory capacities and N-methyl-D-aspartic acid (NMDA) receptor expressions in Shen deficiency constitution (SDC) rats. Totally 40 SD rats were randomly divided into the model group, the Zuogui Pill (ZP) group, the Yougui Pill (YP) group, the blank control group (consisting of normal pregnant rats), 10 in each group. SDC young rat model (inherent deficiency and postnatal malnutrition) was prepared by the classic way of "cat scaring rat". Medication started when they were scared by cat. Rats in the ZP group and the YP group were administered by gastrogavage with ZP suspension 0.1875 g/mL and YP suspension 0.0938 g/mL respectively. Equal volume of normal saline was administered to rats in the blank control group and the model group by gastrogavage. All medication was given once per day, 5 days in a week for 2 consecutive months. Learning and memory capacities were detected by Morris water maze test. Expressi
ISSN:1003-5370