Analysis of cytogenetic characteristics in patients with myelodysplastic syndrome

This study was aimed to investigate the distribution of chromosomal aberrational karyotype in myelodysplastic syndrome (MDS) subgroups, the characterizations of numerical and structural aberration. The chromosome was prepared with simple culture of bone marrow, and the karyotype was analysed by G ba...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 20; no. 6; p. 1405
Main Authors Ma, Liang, Zhong, Ming-Hua, Han, Cheng-Wu, Wang, Jun-Yan, Cao, Yong-Tong, Ma, Yi-Gai
Format Journal Article
LanguageChinese
Published China 01.12.2012
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Chromosome Aberrations
Cytogenetics
Female
Humans
Karyotype
Karyotyping
Male
Middle Aged
Myelodysplastic Syndromes - genetics
Young Adult
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Summary:This study was aimed to investigate the distribution of chromosomal aberrational karyotype in myelodysplastic syndrome (MDS) subgroups, the characterizations of numerical and structural aberration. The chromosome was prepared with simple culture of bone marrow, and the karyotype was analysed by G banding technique. The results showed tht 54 out of 127 patients (42.5%) had clonal chromosome aberrations, and the abnormal rates were different in subgroups: 30% (3/10) in MDS-RA, 35.9% (23/64) in MDS-RCMD, 22.2% (2/9) in MDS-RAS, 45% (9/20) in MDS-RAEB-I, 66.7% (14/21) in MDS-RAEB-II, 100% (3/3) in 5q-syndrome, respectively. Among 54 abnormal chromosome patients, 21 patients showed numerical aberration, 14 patients showed structural aberration, and the other 19 patients showed both numerical and structural aberration. The order of frequent aberrations was as follows complex karyotype (11.02%, 14/127), single +8 (10.24%, 13/127), -7/7q- (3.9%, 5/127), 1q+ (3.15%, 4/127), -X/-Y (3.15%, 4/127), 20q- (2.36%, 3/127), 5
ISSN:1009-2137