A Case of Long-Term Survival of a Patient with Gastric Cancer with Synchronous Liver Metastasis and Portal Vein Thrombus after Multidisciplinary Treatment

• Published in: Gan to kagaku ryoho Vol. 44; no. 6; p. 521
• Main Authors: Nomura, Hajime, Okamura, Masahiko, Sumii, Atsuhiko, Tsuboi, Kunihiko, Mizukami, You, Ota, Syuichi, Adachi, Yukihito
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.06.2017
• Subjects: Aged; Antimetabolites, Antineoplastic - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Capecitabine - administration & dosage; Cisplatin - administration & dosage; Combined Modality Therapy; Drug Combinations; Gastrectomy; Humans; Liver Neoplasms - secondary; Liver Neoplasms - therapy; Male; Oxonic Acid - therapeutic use; Portal Vein - pathology; Portal Vein - surgery; Stomach Neoplasms - pathology; Stomach Neoplasms - therapy; Tegafur - therapeutic use; Time Factors; Trastuzumab - administration & dosage; Venous Thrombosis - etiology
• ISSN: 0385-0684

A 77-year-old man was diagnosed with gastric cancer with synchronous single liver metastasis and portal vein thrombus. His HER2 immunohistochemistry tumor score was 3+; therefore, we administered trastuzumab plus capecitabine plus cisplatin. After 2 courses of chemotherapy, we observed disappearance of the portal vein thrombus and tumor reduction as a partial response, according to the RECIST guidelines. We performed distal gastrectomy and right lobectomy; the therapeutic grades of the primary and metastatic tumors were 1a and 2, respectively. We administered postoperative chemotherapy, and no recurrent lesions have appeared 2 years after surgery. Multidisciplinary treatment for gastric cancer with liver metastasis might be a feasible and useful strategy.