Interleukin-20 and interleukin-22 in pleural effusion

• Published in: Zhonghua jiehe he huxi zazhi Vol. 39; no. 8; p. 608
• Main Authors: Cao, T Z, Du, R H, Lian, Z, Jin, W, Qiu, M
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2016
• Subjects: Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-22; Interleukins - blood; Pleural Effusion - blood; Pleural Effusion, Malignant - blood; Sensitivity and Specificity; Tuberculosis, Pleural - blood
• ISSN: 1001-0939
• DOI: 10.3760/cma.j.issn.1001-0939.2016.08.012

To investigate the concentrations and clinical significance of interleukin (IL)-20 and IL-22 in pleural effusion with various etiologies. Pleural effusion (PE) and corresponding serum samples were obtained from 88 patients from Wuhan Tuberculosis Prevention and Control Institute from June 2011 to June 2013. There were 27 cases with malignant pleural effusion, 24 with tuberculous pleural effusion, 17 with bacterial pleural effusion and 20 with transudativeeffusion. The pleural and serum levels of IL-20 and IL-22 were determined by sandwich enzyme-linked immunosorbent assays (ELISA). (1) Except for transudativeeffusion, the concentration of IL-20 in malignant pleural effusion (36.8±5.1) ng/L, tuberculous pleural effusion (34.8±6) ng/L, bacterial pleural effusion (41.7±20.2) ng/L, were significantly higher than that of the corresponding serum concentration (29.7±5.97) ng/L, (27.3 ±6.7) ng/L, (25.6±4.7) ng/L (t=5.044, 3.804, 3.452, P<0.05). However, the concentration of IL-20 in pleural effusions of different cau