Effect of additional disease (comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant

Analysis of association of allergic rhinitis with the KCNE4 gene rs12621643 variant was conducted in Russian residents of Western Siberia (taking into account comorbidity with bronchial asthma). It was found that, among individuals without bronchial asthma, the frequencies of the KCNE4*G allele and...

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Published inGenetika Vol. 49; no. 4; p. 541
Main Authors Freĭdin, M B, Bragina, E Iu, Saltykova, I V, Deeva, E V, Ogorodova, L M, Puzyrev, V P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.2013
Subjects
Adult
Asthma - epidemiology
Asthma - genetics
Comorbidity
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Potassium Channels, Voltage-Gated - genetics
Rhinitis, Allergic
Rhinitis, Allergic, Perennial - epidemiology
Rhinitis, Allergic, Perennial - genetics
Siberia - epidemiology
Siberia
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Summary:Analysis of association of allergic rhinitis with the KCNE4 gene rs12621643 variant was conducted in Russian residents of Western Siberia (taking into account comorbidity with bronchial asthma). It was found that, among individuals without bronchial asthma, the frequencies of the KCNE4*G allele and KCNE4*G/G genotype are significantly higher in patients with rhinitis compared to individuals without it. At the same time, no association of rs12621643 with rhinitis was detected in the group of individuals with bronchial asthma. The data obtained indicate the association of the KCNE4 gene variability with allergic rhinitis, although the effect of this gene relative to the development of the disease can be leveled against a background of the manifestation of another atopic disease.
ISSN:0016-6758
DOI:10.7868/S001667581304005X