Pharmacokinetics study of curcumin solid lipid nanoparticles by intravenous injection in rats

To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats. Rats were administrated with (iv) curcumin solid lipid nanoparticles and curcumin solution (8.0 mg/kg), respectively. Blood samples were collected and curcumin in blood plasma was determined by HPLC. Compartm...

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Bibliographic Details
Published inZhong yao cai Vol. 37; no. 7; p. 1234
Main Authors Yan, Zi-Jun, Li, Wan-Yu, Sun, Li-Li, Deng, Xue, Wan, Kun, Zhang, Jing-Qing
Format Journal Article
LanguageChinese
Published China 01.07.2014
Subjects
Animals
Biological Availability
Chromatography, High Pressure Liquid
Curcumin - administration & dosage
Curcumin - pharmacokinetics
Infusions, Intravenous
Injections, Intravenous
Lipids
Nanoparticles - administration & dosage
Rats
Rats, Sprague-Dawley
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Summary:To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats. Rats were administrated with (iv) curcumin solid lipid nanoparticles and curcumin solution (8.0 mg/kg), respectively. Blood samples were collected and curcumin in blood plasma was determined by HPLC. Compartmental pharmacokinetics was analyzed by DAS software. After intravenous administration, the AUC(0-t), AUC(0-infinity) and t(1/2) of curcumin solid lipid nanoparticles were 1.50-fold, 1.63-fold and 4.08-fold higher than those of curcumin solution as (173.09 ± 44.81) μg x h/L vs. (114.83 ± 13.19) μg x h/L, (196.56 ± 35.25) μg x h/L vs. (120.66 ± 13.95) μg x h/L and (5.95 ± 2.05) h vs. (1.46 ± 0.03) h. The curcumin solid lipid nanoparticles is eliminated more slowly. The bioavailability of curcumin in rats increases remarkably compared with that of curcumin solution after intravenous administration.
ISSN:1001-4454