Clinical analysis of 45 patients with intracranial germinoma treated by radiotherapy

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 38; no. 3; p. 262
• Main Authors: Hong, Jidong, Wang, Xia, Peng, Yuping, Wang, Longyun, Huo, Lei, Han, Zaide, Tu, Qingsong
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2013
• Subjects: Adolescent; Adult; Antineoplastic Agents - therapeutic use; Brain Neoplasms - drug therapy; Brain Neoplasms - mortality; Brain Neoplasms - radiotherapy; Child; Female; Follow-Up Studies; Germinoma - drug therapy; Germinoma - radiotherapy; Humans; Male; Young Adult
• ISSN: 1672-7347
• DOI: 10.3969/j.issn.1672-7347.2013.03.008

To report the prospective efficacy of 45 patients intracranial germinoma treated by radiotherapy and discuss its treatment. From February 1998 to October 2007, a total of 45 intracranial germinoma patients were performed radiotherapy, including 15 combined chemotherapy in the Department of Oncology. Of them 23 were pathologically diagnosed while 22 cases were clinical diagnosed. Life table method showed the 5-year and 10-year survival rate. Forty patients were followed-up. Most symptoms of the patients were significantly reduced or disappeared completely. The 5-year and 10-year survival rate of all patients were 84% and 74%. Radiotherapy is the main treatment for intracranial germinoma. Craniospinal irradiation, whole brain irradiation and partial brain irradiation are the main treatments. Radiotherapy combined with chemotherapy, which can reduce the radiation range and dose will be the trend.