Prognostic significance of flow cytometric minimal residual disease in acute myeloid leukemia during aplasia

• Published in: Zhōnghuá xuèyèxué zázhì Vol. 38; no. 9; pp. 767 - 771
• Main Authors: Peng, N, Wei, H, Lin, D, Zhou, C L, Liu, B C, Wang, Y, Liu, K Q, Gong, B F, Wei, S N, Zhang, G J, Liu, Y T, Gong, X Y, Qiu, S W, Mi, Y C, Wang, J X
• Format: Journal Article
• Language: Chinese
• Published: China 14.09.2017
• Subjects: Adolescent; Adult; Female; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm, Residual; Prognosis; Remission Induction; Retrospective Studies; Young Adult; Leukemia, myeloid, acute; Minimal residual disease; Prognosis; Multiparameter flow cytometry
• ISSN: 0253-2727
• DOI: 10.3760/cma.j.issn.0253-2727.2017.09.007

To investigate the impact of minimal residual disease (MRD) by multiparameter flow cytometry (MPFC) during aplasia on efficacy and prognosis of de novo acute myeloid leukemia (AML) (non M(3)) patients. The MRD data by 8-color MPFC during aplasia (day 14-15 of induction therapy) in 85 de novo AML (non M(3)) patients and the MRD impact on efficacy and prognosis were retrospectively analyzed. Data of 85 patients, including 42 males (49.4%) and 43 females (50.6%) , were collected, with a median age of 35 (15-54) years. The median MRD by MPFC during aplasia was 0.58% (0-81.11%) , and 70 (82.4%) patients achieved complete remission (CR) after first induction chemotherapy. The cutoff of MRD by receiver operating characteristic (ROC) analysis was 2.305% (Se= 0.867, Sp=0.800) . The CR rate after one course was significantly higher in patients with MRD<2.305% [96.6% (56/58) ]than in patients with MRD≥2.305%[51.9% (14/27) ] ( (2)=22.348, <0.001) ; no significant difference with respect to relapse-free survival rate ( (2