Combinatorial Use of Rapid-Onset Opioid and Short-Acting Opioid Is Effective against Breakthrough Cancer Pain

Breakthrough cancer pain is divided into "predictable breakthrough pain" and "unpredictable breakthrough pain". Uncontrolled breakthrough pain in cancer negatively affects the quality of life of the patients. The short-acting opioid(SAO) requires considerable time to produce anal...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 45; no. 4; p. 625
Main Authors Shikada, Yasunori, Emi, Yasunori, Kometani, Takuro, Ochiai, Toshiaki, Fujii, Misa, Noda, Yoko, Kajiwara, Mie, Ikeda, Munehiko, Asonuma, Shinichi, Mori, Minami
Format Journal Article
LanguageJapanese
Published Japan 01.04.2018
Subjects
Adult
Aged
Analgesics, Opioid - therapeutic use
Cancer Pain - drug therapy
Drug Combinations
Female
Humans
Male
Middle Aged
Pain Management
Time Factors
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Summary:Breakthrough cancer pain is divided into "predictable breakthrough pain" and "unpredictable breakthrough pain". Uncontrolled breakthrough pain in cancer negatively affects the quality of life of the patients. The short-acting opioid(SAO) requires considerable time to produce analgesia, and is not adequate as a rescue drug. The rapid-onset opioid(ROO)immediately produces analgesia, but its appropriate usage is difficult. For instance, the frequency and interval of ROO usage is limited, making the optimization of dosage cumbersome. Therefore, ROO has not yet gained popularity. Here, we report that a combinatorial use of ROO and SAO is effective against breakthrough cancer pain, with SAO and ROO being suitable for "predictable breakthrough pain", and "unpredictable breakthrough pain", respectively. The effectiveness and safety of this combination were assessed for many patients with breakthrough cancer pain.
ISSN:0385-0684