The changes in the biochemical indices of blood in cobalt intoxication on the background of the regulators of the expression of endothelial NO-synthase

• Published in: Patologicheskaia fiziologiia i eksperimental'naia terapiia no. 4; p. 66
• Main Authors: Dzugkoev, S G, Mozhayeva, I V, Gigolaeva, L B, Tedtoeva, A I, Margieva, O I, Dzugkoeva, F S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.10.2014
• Subjects: Animals; Antioxidants - metabolism; Arginine - administration & dosage; Arginine - deficiency; Arginine - pharmacology; Biomarkers - blood; Catalase - blood; Cholesterol - blood; Cobalt - toxicity; Endothelium, Vascular - drug effects; Endothelium, Vascular - enzymology; Endothelium, Vascular - metabolism; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Male; NG-Nitroarginine Methyl Ester - administration & dosage; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - blood; Nitric Oxide Synthase Type III - biosynthesis; Oxidative Stress - drug effects; Rats, Wistar; Superoxide Dismutase - blood; Ubiquinone - administration & dosage; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology
• ISSN: 0031-2991

On the background of chronic cobalt intoxication in rats develops oxidative stress. This is accompanied by a decrease in the content of total metabolites of nitric oxide in the blood serum. The reasons for lower levels of the vasodilatation factor are the following: a deficiency of L-arginine and the increase in the content of the inhibitor of NOS-3. We found a decrease in the bioavailability of nitric oxide due to the increase in the content of oxidized low density lipids, total cholesterol and cholesterol-lowering lipids high density.