Molecular epidemiology of HFMD-associated pathogen coxsackievirus A6 in Fujian Province, 2011-2013

In order to characterize the molecular epidemiology of HFMD-associated Coxsackievirus A6 (CVA6) in Fujian Province, a total of 1340 specimens from non-EV71 non-CVA16 HFMD patients were collected during 2011-2013. Isolated virus strains were identified and subtyped. Full-length coding regions for the...

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Published inBingdu xuebao Vol. 30; no. 6; p. 624
Main Authors Chen, Wei, Weng, Yu-wei, He, Wen-xiang, Zhang, Yong-jun, Yang, Xiu-hui, Meng, Huang, Xie, Jian-feng, Wang, Jin-zhang, Zheng, Kui-cheng, Yan, Yan-sheng
Format Journal Article
LanguageChinese
Published China 01.11.2014
Subjects
Child
Child, Preschool
China - epidemiology
Enterovirus A, Human - classification
Enterovirus A, Human - genetics
Enterovirus A, Human - isolation & purification
Evolution, Molecular
Female
Hand, Foot and Mouth Disease - epidemiology
Hand, Foot and Mouth Disease - virology
Humans
Infant
Male
Molecular Epidemiology
Molecular Sequence Data
Phylogeny
China
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Summary:In order to characterize the molecular epidemiology of HFMD-associated Coxsackievirus A6 (CVA6) in Fujian Province, a total of 1340 specimens from non-EV71 non-CVA16 HFMD patients were collected during 2011-2013. Isolated virus strains were identified and subtyped. Full-length coding regions for the VP1 gene of the predominant serotype CVA6 isolates were amplified and sequenced. Among the 375 non-EV71 non-CVA16 HFMD cases confirmed by virus isolation and molecular subtyping, 182 (48.5%) were found to be caused by CVA6, accounting for 7.9%, 16.2% and 39.6% HFMD-associated enteroviruses in FujianProvince during 2011, 2012, and 2013, respectively. Compared with general features observed in the HFMD epidemic, no difference in CVA6-specificity or severity rates was observed between geographical origins, gender, or age groups. Nucleotide sequence analyses of VP1 genes revealed high diversity levels of 16.2%-18.6% among CVA6 strains from Fujian Province, in contrast to the prototype CVA6 strain, and showed low level
ISSN:1000-8721