A preliminary investigation of relationship between serum apelin level and pulmonary artery pressure in children with congenital heart disease

• Published in: Zhongguo dang dai er ke za zhi Vol. 18; no. 4; pp. 340 - 344
• Main Authors: Ma, Chao, Shen, Ding-Rong, Zhang, Qing, Ding, Yi-Qun, Wang, Yuan-Xiang, Peng, Le, Meng, Bao-Ying, Ti, Yun-Xing
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2016
• Subjects: Apelin; Blood Pressure; Child, Preschool; Female; Heart Defects, Congenital - blood; Heart Defects, Congenital - physiopathology; Humans; Hypertension, Pulmonary - blood; Infant; Intercellular Signaling Peptides and Proteins - blood; Male; Pulmonary Artery - physiopathology
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2016.04.012

To preliminarily investigate the relationship between serum apelin level and pulmonary artery pressure in children with congenital heart disease. One hundred and twenty-six children with congenital heart disease undergoing surgical treatment were enrolled as subjects. The serum level of apelin was determined before surgery and at 7 days after surgery. The ratio of pulmonary artery systolic pressure to aortic systolic pressure (Pp/Ps) was calculated before extracorporeal circulation. According to the Pp/Ps value, patients were classified into non-pulmonary arterial hypertension (PAH) group, mild PAH group, moderate PAH group, and severe PAH group. Pulmonary artery mean pressure was estimated by echocardiography at 7 days after surgery. The non-PAH group had the highest serum level of apelin before and after surgery, followed by the mild PAH group, moderate PAH group, and severe PAH group (P<0.05). All groups had significantly increased serum levels of apelin at 7 days after surgery (P<0.05). The serum level of