Ratio balance of Th17 and Treg cells in peripheral blood of patients with chronic lymphocytic leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 21; no. 2; p. 329
• Main Authors: Tang, Di-Jiao, Niu, Qian, Zeng, Ting-Ting, Jiang, Neng-Gang, Jin, Yong-Mei, Ding, Bin, Zheng, Qin, Shi, Qing, Chen, Jiao, Yu, Jiang, Su, Jun, Jia, Yong-Qian
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2013
• Subjects: Aged; Case-Control Studies; Female; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Lymphocyte Count; Male; Middle Aged; T-Lymphocytes, Regulatory - cytology; Th17 Cells - cytology
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2013.02.014

This study was purposed to investigate the ratio of Th17 cells and CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells in peripheral blood of patients with chronic lymphocytic leukemia (CLL) and to explore their roles in the pathogenesis and clinical diagnosis. Based on the number of peripheral lymphocytes and treatment condition, the CLL patients were divided into 2 groups: untreated group (n = 30) and remission group (n = 15), the healthy control group (n = 20) was set up as well. The frequencies of Th17 and Treg cells of all cases were detected by flow cytometry (FCM). The results showed that frequencies of CD3(+)CD4(+)T cells and Th17 cells were significantly higher in untreated group than that in healthy control group (P < 0.05), the frequencies of CD3(+)CD8(+)T cells and Treg cells were significantly lower in untreated group than that in healthy control group (P < 0.05), the ratio of Th17/Treg was significantly higher in untreated group than that in healthy control group (P < 0.05). The frequencies of Th17