Expression and significance of INSM1 and SOX11 in pancreatic neuroendocrine tumor and solid pseudopapillary neoplasm

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 55; no. 4; pp. 575 - 581
• Main Authors: Cao, Z, Cen, H B, Zhao, J H, Mei, J, Qin, L Z, Liao, W, Ao, Q L
• Format: Journal Article
• Language: Chinese
• Published: China 18.08.2023
• Subjects: beta Catenin; Biomarkers, Tumor; Humans; Neuroectodermal Tumors, Primitive; Neuroendocrine Tumors - diagnosis; Neuroendocrine Tumors - metabolism; Neuroendocrine Tumors - pathology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Repressor Proteins - genetics; Repressor Proteins - metabolism; SOXC Transcription Factors; SRY-related high-mobility group box 11; Biomarkers, tumor; Pancreatic neoplasms; Insulinoma associated protein 1; Neuroendocrine tumors
• ISSN: 1671-167X
• DOI: 10.19723/j.issn.1671-167X.2023.04.001

To investigate the expression and significance of insulinoma associated protein 1 (INSM1) and SRY-related high-mobility group box 11 (SOX11) in pancreatic neuroendocrine tumor (PNET) and solid pseudopapillary neoplasm (SPN). To detect the expression of INSM1, SOX11, Syn, CgA, CD56, β-catenin, and CD99 in 56 cases of PNET, 42 cases of SPN, 16 cases of ductal adenocarcinoma (DACC) and 8 cases of acinar cell carcinoma (ACC) by immunohistochemistry. The application value of combination of INSM1 and SOX11 was compared with conventional markers (Syn, CgA, CD56, β-catenin, and CD99) in diagnosis and differential diagnosis of PNET and SPN. (1) In the 56 cases of PNET, the positive signals of INSM1 were located in the tumor and islet nucleus, the positive expression rate in the tumor tissues was 91.07% (51/56), whereas the signal was absent in 42 cases of SPN, 16 cases of DACC and 8 cases of ACC, and there were significant statistical difference between PNET with SPN, DACC, and ACC respectively ( < 0.001). (2) The pos