Effects of encircled needling plus electroacupuncture on hyperplastic mammary glands and serum sex hormones in the rat

• Published in: Zhēncì yánjiū Vol. 37; no. 3; p. 173
• Main Authors: Yang, Ji-Jun, Wang, Li-Na, Xiao, Hong-Ling, Zhang, Shuan-Cheng, She, Yan-Fen, Bian, Wen-Jing, Guo, Shuai
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2012
• Subjects: Animals; Electroacupuncture - instrumentation; Female; Gene Expression Regulation; Gonadal Steroid Hormones - blood; Hyperplasia - blood; Hyperplasia - metabolism; Hyperplasia - pathology; Hyperplasia - therapy; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - pathology; Needles; Nipples - pathology; Organ Size; Rats; Rats, Wistar; Receptors, Estrogen - metabolism
• ISSN: 1000-0607

To observe the effect of encircled needling plus electroacupuncture (EA) of the second pair of nipples on hyperplastic mammary glands, serum estradiol (E2), progesterone (P), prolactin (PRL) and testosterone (T) contents, estrogen receptor (ER) expression of the mammary glands in mammary hyperplasia rats. Forty Wistar rats were equally randomized into normal control, model, acupuncture and medication groups. Mammary gland hyperplasia model was established by intramuscular injection of diethylstilbestrol (0.5 mg/kg, once daily for 25 days) and progesterone (4 mg/kg, once daily for 5 days). For rats of the acupuncture group, 4 filiform needles were inserted into the surrounding tissues of the second pair of breasts, respectively, followed by giving the animal with EA stimulation for 30 min. Another one acupuncture needle was inserted into "Danzhong" (CV 17) and retained for 30 min. For rats of the medication group, tamoxifen solution (1.8 mg/kg) was given by gavage. Both medication and EA intervention were give