Progress of Researches on Protective Effect of Acupuncture and Moxibustion in Relieving Intracellular Calcium Overload of Cradiomyocytes

Myocardial contraction and relaxation are regulated by increases and decreases of the intracellular cytoplasmic calcium (Ca ) concentration. Intracellular calcium ion is also a ubiquitous second messenger, and its related signal transduction pathways involve a variety of physiological activities and...

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Bibliographic Details
Published inZhēncì yánjiū Vol. 41; no. 3; p. 276
Main Authors Xiao, Yan, Gu, Yi-Huang, Chen, Hao
Format Journal Article
LanguageChinese
Published China 25.06.2016
Subjects
Acupuncture Therapy
Calcium - metabolism
Calcium Channels, L-Type - metabolism
Calcium-Transporting ATPases - metabolism
Humans
Moxibustion
Myocardial Ischemia - therapy
Myocytes, Cardiac - metabolism
Nitric Oxide - metabolism
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Summary:Myocardial contraction and relaxation are regulated by increases and decreases of the intracellular cytoplasmic calcium (Ca ) concentration. Intracellular calcium ion is also a ubiquitous second messenger, and its related signal transduction pathways involve a variety of physiological activities and pathological changes. It has been well documented that intracellular calcium overload is involved in myocardial cellular injury. In the present paper, the authors make a review about experimental researches on the underlying mechanisms of acupuncture and moxibustion in the prevention and treatment of ischemic myocardial injury from reducing calcium overload in recent 10 years. Results of recent studies indicate that acupuncture and moxibustion interventions have a cardioprotective effect by raising Ca -ATPase activity and nitric oxide content, lowering L-type voltage depen-dent calcium channel activity, and ameliorating calcium overload in ischemic cardiomyocytes mainly through cytomembrane, sarcoplasmic reticulum
ISSN:1000-0607