Causes of insufficient anticoagulation in Chinese patients with non-valvlar atrial fibrillation

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 41; no. 11; p. 931
• Main Authors: Gao, Peng, Fang, Quan, Wang, Jia-li, Fan, Jing-bo, Zhu, Kong-bo, Yang, De-yan, Deng, Hua, Cheng, Kang-an
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2013
• Subjects: Administration, Oral; Aged; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Atrial Fibrillation - drug therapy; Female; Humans; Male; Middle Aged; Regression Analysis; Warfarin - administration & dosage; Warfarin - therapeutic use
• ISSN: 0253-3758
• DOI: 10.3760/cma.j.issn.0253-3758.2013.11.008

To evaluate the factors responsible for the insufficient application of oral anticoagulation (OAC) in Chinese patients with non-valvular atrial fibrillation. The research is a single center registration study in a tertiary referral hospital in Beijing. The general characteristics, history of atrial fibrillation, comorbidities and anticoagulation treatment were obtained from all patients.Factors affecting the oral Walfarin use were evaluated by univariable and multivariable regression analysis. OAC therapy with Walfarin was applied on Only 214(39.4%) out of 576 consecutive patients with non-valvular atrial fibrillation. The OAC rate was 30.3% among non-ablation patients. Patients with persistent atrial fibrillation, diabetes, chronic heart failure, history of ischemic stroke/TIA and higher CHA2DS2-VASc score were more likely prescribed with Walfarin. Multivariable regression analysis showed that persistent fibrillation, history of chronic heart failure, ischemic stroke/TIA and non-coronary heart disease predic