Performance of computer-assisted imaging system in detection of squamous intraepithelial lesion of uterine cervix

• Published in: Zhonghua bing li xue za zhi Vol. 42; no. 8; p. 543
• Main Authors: Gao, Ying-zhuo, Huo, Yun-long, Sun, Han-xue, Qi, Ya-fei, Wang, Jin-ou, Lü, Qing-jie
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2013
• Subjects: Carcinoma, Squamous Cell - pathology; Cervical Intraepithelial Neoplasia - pathology; Female; Humans; Image Interpretation, Computer-Assisted; Papillomaviridae - isolation & purification; Papillomavirus Infections - pathology; Uterine Cervical Dysplasia - pathology; Uterine Cervical Neoplasms - pathology; Vaginal Smears - methods
• ISSN: 0529-5807
• DOI: 10.3760/cma.j.issn.0529-5807.2013.08.009

To evaluate the performance of computer-assisted imaging system in the detection of cervical squamous intraepithelial lesion and quality-assurance. Manual PAP screening (n = 140 580) and image-assisted screening (n = 32 885) were compared for the detection rates of squamous cell abnormalities, the atypical squamous cells (ASC) to squamous intraepithelial lesion (SIL) ratio, the positive rates of high risk human papillomavirus (HR-HPV) test in the case of atypical squamous cells of undetermined significance (ASC-US), and the correlation between cytopathology and histopathology. Compared with manual screening, computer-assisted imaging system showed increased overall positive detection by 0.32%, decreased detection of ASC by 0.21%, increased detection of low-grade squamous intraepithelial lesion (LSIL) by 0.22%, increased detection of high-grade squamous intraepithelial lesion or worse (HSIL) by 0.31%, and decreased ASC to SIL ratio from 2.59 to 1.60. Computer-assisted imaging system did not change the HR-HPV p