Protective Activity of Prion Protein Fragments after Immunization of Annimals with Experimentally Induced Alzheimer's Disease

The prion protein is considered as one of the membrane targets of neurotoxic beta-amyloid during Alzheimer's disease development. We have chosen and synthesized 17-33, 23-33, 95-110 and 101-115 prion fragments involved in beta-amyloid binding. The effect of immunization with the peptides on the...

Full description

Saved in:
Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 41; no. 2; p. 145
Main Authors Volpina, O M, Volkova, T D, Medvinskaya, N I, Kamynina, A V, Zaporozhskaya, Y V, Aleksandrova, I J, Koroev, D O, Samokhin, A N, Nesterova, I V, Deygin, V I, Bobkova, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2015
Subjects
Alzheimer Disease - immunology
Alzheimer Disease - physiopathology
Alzheimer Disease - prevention & control
Animals
Disease Models, Animal
Immunization
Peptides - immunology
Peptides - pharmacology
Prions - immunology
Prions - pharmacology
Online AccessGet more information

Cover

More Information
Summary:The prion protein is considered as one of the membrane targets of neurotoxic beta-amyloid during Alzheimer's disease development. We have chosen and synthesized 17-33, 23-33, 95-110 and 101-115 prion fragments involved in beta-amyloid binding. The effect of immunization with the peptides on the features of Alzheimer's disease was investigated in animals with an experimentally induced form of the disease. It was shown that immunization either with peptide 17-33 or with protein conjugates of peptides 23-33 and 101-115 increases the level of brain beta-amyloid and improves morfofunctional state of the brain.
ISSN:0132-3423
DOI:10.7868/s0132342315020165