Research Progress of Immunity Mechanism in Hypertension

Hypertension, which can cause a variety of cardiovascular and cerebrovascular complications, is a serious threat to human health. Currently, it is found that hypertension is related to immunoregulatory abnormality, which could lead to chronic inflammation. Then the chronic inflammation may impair va...

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Bibliographic Details
Published inSheng li kʻo hsüeh chin chan Vol. 47; no. 4; p. 255
Main Authors Liu, Long-Zhu, He, Xi, Xu, Man, Yu, Xiao-Jiang, Zang, Wei-Jin
Format Journal Article
LanguageChinese
Published China 01.08.2016
Subjects
Animals
Cardiovascular Diseases
Humans
Hypertension - etiology
Hypertension - physiopathology
Immunity, Innate
Inflammation
Renin-Angiotensin System
T-Lymphocytes
Toll-Like Receptors - physiology
Vascular Remodeling
Vasoconstriction
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Summary:Hypertension, which can cause a variety of cardiovascular and cerebrovascular complications, is a serious threat to human health. Currently, it is found that hypertension is related to immunoregulatory abnormality, which could lead to chronic inflammation. Then the chronic inflammation may impair vascular endothelial function and activate renin-angiotensin system, which cause vascular remodeling, angiosclerosis, dysfunctional vasoconstriction and vasodilatation, and exacerbate hypertension. The immunoregulatory abnormality of hypertension involves macrophage infiltration of the organization, the dendritic cell of antigen presentation and natural killer cells of activation in nonspecific immunity and activation of T cells in specific immune. The key of immunity mechanism of hypertension is the Toll like receptor to activate immune system and lead to inflammation. Autonomic nervous system is also closely related to the development and progression of hypertension. Autonomic imbalance in hypertension leads to imm
ISSN:0559-7765