Association between human leukocyte antigen and nasopharyngeal-carcinoma

Nasopharyngeal carcinoma (NPC) is characterized by its distinct racial and geographical distribution with a multifactorial etiology. It has been well accepted that NPC is related to Epstein-Barr(EB) virus infection but environmental and genetics factors also play critical roles. Among host genetic m...

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Bibliographic Details
Published inYíchuán Vol. 34; no. 12; p. 1505
Main Authors Tang, Min-Zhong, Cai, Yong-Lin, Zheng, Yu-Ming, Zeng, Yi
Format Journal Article
LanguageChinese
Published China 01.12.2012
Subjects
Carcinoma
Genetic Association Studies
HLA Antigens - genetics
Humans
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - genetics
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Summary:Nasopharyngeal carcinoma (NPC) is characterized by its distinct racial and geographical distribution with a multifactorial etiology. It has been well accepted that NPC is related to Epstein-Barr(EB) virus infection but environmental and genetics factors also play critical roles. Among host genetic markers associated with NPC, the highly variable class I human leukocyte antigen (HLA) genes on chromosome 6 (6p21.3) have shown a strong and consistent association with NPC risk. As the consequence of new generation DNA sequencing technologies used in HLA genotyping, the number of the reported HLA new alleles is dramaticllyincreasing, and more full length sequences of HLA alleles have been reported. The significant association between HLA genes and NPC has been identifiedin a series of studies, including HLA association study, linkage disequilibrium study for microsatellite markers, and genome wide association study. In this review, we summarize association studies between HLA and NPC to evaluate the role of geneti
ISSN:0253-9772
DOI:10.3724/SP.J.1005.2012.01505