The effect of inhaled nitric oxide on endothelium-derived angiokinetic factors in patients with acute high altitude disease

• Published in: Zhonghua jiehe he huxi zazhi Vol. 30; no. 2; p. 127
• Main Authors: Zheng, Bi-hai, Li, Su-zhi, He, Yi, Wang, Hong-bin, Li, Shang-shi
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2007
• Subjects: 6-Ketoprostaglandin F1 alpha - blood; Administration, Inhalation; Adolescent; Altitude Sickness - metabolism; Endothelins - blood; Endothelium - metabolism; Humans; Male; Nitric Oxide - administration & dosage; Nitric Oxide - blood; Nitric Oxide - therapeutic use; Thromboxane B2 - blood; Young Adult
• ISSN: 1001-0939

To study the effect of inhaled nitrogen monoxidum (NO) on endothelium-derived angiokinetic factors including NO, endothelin (ET), thromboxane B(2) (TXB(2)) and 6-keto-prostaglandin F(1a) (6-Keto-PGF(1a)) in patients with acute high altitude disease. Forty-seven patients with acute high altitude disease were selected and divided into two groups randomly: twenty-three cases as a routine medical treatment group, for which oxygen, aminophylline, dexamethasone and furosemide were used, while 24 cases as a NO treatment group, for which only inhalation of 0.001% NO gas with air balanced in plateau (altitude 3658 m), were given twice daily (AM and PM each for an hour). The level of serum NO, ET, TXB(2) and 6-Keto-PGF(1a) were measured, and the changes of clinical symptoms were scored using the Lake Louise acute high altitude disease scoring. In the two groups, the level of ET [(78 +/- 8) and (69 +/- 5) ng/L], TXB(2) [(87 +/- 13) and (73 +/- 8) ng/L], ET/NO [(26.7 +/- 1.5) x 10(3) and (21.8 +/- 1.1) x 10(3)], TXB(2)/6