Clinicopathologic analysis of the nipple-areolar complex occult involvement in early stage breast carcinoma

The aim of this study was to investigate the incidence of nipple-areola complex (NAG) involvement in stage I - II a breast cancer patients who underwent skin-sparing mastectomy and to determine the associated risk factors, to provide a theoretical basis for modified radical mastectomy preserving NAC...

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Bibliographic Details
Published inZhōnghuá zhŏngliú zázhì Vol. 30; no. 3; p. 203
Main Authors Wang, Sheng-Ying, Peng, De-Feng, Cai, Zhao-Gen, Zhang, Rong-Zin, Yao, Ting-Jing, Zhang, Hui, Yang, Ming, Dong, Hui-Ming
Format Journal Article
LanguageChinese
Published China 01.03.2008
Subjects
Adult
Aged
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - surgery
Carcinoma, Intraductal, Noninfiltrating - metabolism
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - surgery
Female
Humans
Lymphatic Metastasis
Mammaplasty
Mastectomy, Modified Radical
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Nipples - pathology
Nipples - surgery
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Tumor Burden
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Summary:The aim of this study was to investigate the incidence of nipple-areola complex (NAG) involvement in stage I - II a breast cancer patients who underwent skin-sparing mastectomy and to determine the associated risk factors, to provide a theoretical basis for modified radical mastectomy preserving NAC and breast reconstruction in early stage breast cancer patients. A total of 68 women with primary breast cancer were included in this study. The following associated risk factors of NAC involvement were assessed and compared with those of non-involvement: the distance from the tumor site to the edge of areola (D), axillary lymph node status, over-expression of HER-2/neu, location of tumor, TNM stage, abnormal nipple (nipple indentation, erosion, discharge), tumor size, age, histological type, as well as status of estrogen receptor (ER) and progesterone receptor (PR), by Chi-square test. The positive rate of NAG involvement was 13.2%. It decreased with an increase in the distance from the tumor site to the edge of
ISSN:0253-3766