Efficacy of amiodarone versus propafenone in the prevention of rhythm disorders in patients after aortocoronary bypass surgery

A prospective randomized study was conducted to compare the antiarrhythmic activity of amiodarone and propafenone used to prevent atrial fibrillation (AF) after aortocoronary bypass surgery (ACBS). The study included 100 patients who had undergone myocardial revascularization. The patients were divi...

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Bibliographic Details
Published inAnesteziologiia i reanimatologiia no. 5; p. 45
Main Authors Eremenko, A A, Galanikhina, E A, Ziuliaeva, T P, Egorov, V M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2010
Subjects
Administration, Oral
Adult
Aged
Amiodarone - administration & dosage
Amiodarone - therapeutic use
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - therapeutic use
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - prevention & control
Coronary Artery Bypass - adverse effects
Female
Humans
Injections, Intravenous
Male
Middle Aged
Propafenone - administration & dosage
Propafenone - therapeutic use
Prospective Studies
Treatment Outcome
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Summary:A prospective randomized study was conducted to compare the antiarrhythmic activity of amiodarone and propafenone used to prevent atrial fibrillation (AF) after aortocoronary bypass surgery (ACBS). The study included 100 patients who had undergone myocardial revascularization. The patients were divided into 2 groups that did not significantly differ in their baseline condition, history data, the type of a surgical intervention, and the incidence of postoperative complications. Antiarrhythmic therapy was initiated within the first 24 hours after surgery. Group 1 (n=50) was given intravenous amiodarone in a dose of 6 mg/kg/day. Rhythm disturbances occurred in 13 (26%) patients. Group 2 (n=50) received oral propaferone in a dose of 6.6 mg/kg/day. AF occurred in 5 (10%) patients. The difference between Groups 1 and 2 was statistically significant (p = 0.047). The preventive use of propafenone recovered sinus rhythm in earlier periods (4602 +/- 71 min) than that of amiodarone (760 +/- 82 min); p = 0.049. Thus, propafenone was found to be a more effective drug used to prevent AF after ACBS, which is attributable to different pharmacodynamic behavior of the agents.
ISSN:0201-7563