Investigation of metabolic paramagnetic centers in the blood of patients with prostate adenocarcinoma prior to and after the plastic orchectomy

Paramagnetic centers in the blood of patients with prostate adenocarcinoma have been studied prior to and after plastic orchectomy by EPR. It has been shown that significant alterations in blood paramagnetic centers occur after the surgery. These alterations point to an improvement of antioxidant pr...

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Bibliographic Details
Published inBiofizika Vol. 56; no. 4; p. 742
Main Authors Kotrikadze, N G, Khutsishvili, E G, Chelidze, M Z, Alibegashvili, M R, Artsivadze, K L, Sanikidze, T V, Managadze, L G, Chigogidze, T G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2011
Subjects
Adenocarcinoma - blood
Adenocarcinoma - surgery
Aged
Electron Spin Resonance Spectroscopy
Humans
Iron - blood
Male
Methemoglobin - metabolism
Middle Aged
Prostatic Neoplasms - blood
Prostatic Neoplasms - surgery
Receptors, Adrenergic - blood
Transferrin - metabolism
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Summary:Paramagnetic centers in the blood of patients with prostate adenocarcinoma have been studied prior to and after plastic orchectomy by EPR. It has been shown that significant alterations in blood paramagnetic centers occur after the surgery. These alterations point to an improvement of antioxidant properties of the blood. Specifically, the content of the Fe(3+)-transferrin complexes increased, and the number of inactivated adrenoreceptors, MetHb, and Mn(2+)-containing complexes decreased. It was found that, along with improvement of the antioxidant properties of the blood, a significant decrease in the intensity of lipid peroxidation in the blood of the patients occurs.
ISSN:0006-3029