Levels of serum brain natriuretic peptide and the correlation to heart function in children with Kawasaki disease

• Published in: Zhongguo dang dai er ke za zhi Vol. 12; no. 3; p. 169
• Main Authors: Sun, Yu-Ping, Wang, Wen-Di, Zheng, Xing-Chang, Wang, Jin-Ju, Ma, Shao-Chun, Xu, Ying-Jun
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2010
• Subjects: Child; Child, Preschool; Female; Heart - physiopathology; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome - blood; Mucocutaneous Lymph Node Syndrome - diagnosis; Mucocutaneous Lymph Node Syndrome - physiopathology; Natriuretic Peptide, Brain - blood
• ISSN: 1008-8830

To study serum levels of brain natriuretic peptide (BNP) in children with Kawasaki disease (KD) and the correlation between BNP levels and the heart function. Forty-three children with KD and thirty healthy children were enrolled. Serum levels of BNP were measured using ELISA. KD children received an echocardiographic examination, including measurements of left ventricular ejection fraction (LVEF), left ventricular shorten fraction (LVSF), cardiac index (CI) and left ventricular inflow velocity through the mitral annulus. Mean serum level of BNP at the acute stage in children with KD was significantly higher than that at the recovery stage as well as the control group (p<0.01). The LVEF, LVSF and CI levels at the acute stage were significantly lower than those at the recovery stage in children with KD (p<0.05). The linear regression analysis showed that the BNP level was negatively correlated with the levels of LVEF, LVSF and CI (r=-0.63, -0.52, -0.53, p<0.05). The serum BNP levels increase significantly in K