Study on in vitro release and transdermal behaviors of mumps cataplasm of complex prescription

To investigate the in vitro release and transdermal behaviors of mumps cataplasm of complex prescription. The improved Franz difficusion was used and the concentration of drugs was detected. DCS was determined by HPLC and flavanoid contents were determined by UV. The accumulation skin permeation per...

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Bibliographic Details
Published inZhong yao cai Vol. 33; no. 8; p. 1330
Main Authors Song, Jin-yan, Guo, Zeng-jun, Zheng, Na, Wu, Nan, Mao, Jun-jun, Pang, Xiao-ming
Format Journal Article
LanguageChinese
Published China 01.08.2010
Subjects
Administration, Cutaneous
Animals
Antiviral Agents - administration & dosage
Antiviral Agents - pharmacokinetics
Chromatography, High Pressure Liquid
Diclofenac - administration & dosage
Diclofenac - analysis
Diclofenac - pharmacokinetics
Drug Combinations
Flavonoids - analysis
Flavonoids - pharmacokinetics
Mice
Mumps - drug therapy
Opuntia - chemistry
Plant Extracts - administration & dosage
Plant Extracts - pharmacokinetics
Skin - metabolism
Skin Absorption
Technology, Pharmaceutical - methods
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Summary:To investigate the in vitro release and transdermal behaviors of mumps cataplasm of complex prescription. The improved Franz difficusion was used and the concentration of drugs was detected. DCS was determined by HPLC and flavanoid contents were determined by UV. The accumulation skin permeation percentage of DCS and flavanoid was 32% and 21%, respectively, the in vitro release percentage of DCS and flavanoid was 47% and 42%, respectively. The transdermal behavior of mumps cataplasm of complex prescription is an zero-order kinetics progress. The in vitro release behavior is in accordance with the Higuchi equation.
ISSN:1001-4454