Impact of surgical operation-related factors on long-term survival of patients with hepatocellular carcinoma after hepatectomy

• Published in: Zhōngguó yīxué kēxuéyuàn xuébào Vol. 30; no. 4; p. 386
• Main Authors: Lü, Wen-ping, Dong, Jia-hong, Zhang, Wen-zhi, Huang, Xiao-qiang, Wang, Shu-guang, Bie, Ping
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2008
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Child; Female; Hepatectomy - adverse effects; Humans; Intraoperative Complications; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult
• ISSN: 1000-503X
• DOI: 10.3881/j.issn.1000-503X.2008.04.006

To evaluate the prognostic value of surgical operation-related factors in patients with hepatocellular carcinoma (HCC). The clinical data of 234 patients after hepatic resection (214 men and 20 women) were retrospectively studied. Univariate and multivariate COX regression analyses were performed for surgical operation-related prognostic factors including age, gender, intraoperative blood loss, iatrogenic tumour rupture, transfusion, operation duration, hepatectomy extent, Pringle manoeuvre, with or without devarscularization, and complications (e.g. postoperative ascites, biliary leakage, incision infection, and pleural effusion). Kaplan-Meier and log-rank tests were used to compare survival rates. Kendall's tau bivariate analyses were used to examine the correlations of these surgical operation-related factors. Univariate COX regression analysis revealed that iatrogenic blood loss (chi2 = 19.721, P < 0.001), transfusion (chi2 = 7.769, P = 0.005), tumour rupture (chi2 = 6.401, P = 0.011), operation duration