Relationship between FAS/FASL gene polymorphisms and susceptibility of coal worker's pneumoconiosis

• Published in: Zhonghua laodong weisheng zhiyebing zazhi Vol. 25; no. 9; p. 532
• Main Authors: Ni, Chun-hui, Song, Zhi-fang, Jia, Xiao-min, Li, Ai-ping, Li, Chun-ping, Li, Shao-kui, Li, Yu-ming, Wang, Zhi-lai, Zhou, Yin, Wang, Shou-yu, Zhang, Zheng-dong, Zhou, Jian-wei
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2007
• Subjects: Adult; Aged; Aged, 80 and over; Anthracosis - genetics; China; Fas Ligand Protein - genetics; fas Receptor - genetics; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Genetic
• ISSN: 1001-9391

To investigate the effects of FAS and FASL gene polymorphisms on genetic susceptibility of coal worker's pneumoconiosis and their relationship to the pulmonary fibrosis. 340 with coal worker's pneumoconiosis (CWP) and 312 coal mine workers (controls) exposed to the coal dusts were selected. FAS-1377G > A, FAS-670A > G and FASL-844T > C gene polymorphisms were analyzed by PCR-RFLP techniques. The distribution frequencies of genotypes of FAS-1377, FAS-670, FASL-844 genotypes in CWP had no significant differences compared to the control. Compared to CWP patients with exposure year > or = 25, the risk of pneumoconiosis with FAS-1377 GA/AA genotype was significantly higher than those with FAS-1377GG in the patients working age < 25 years (P = 0.098, 95% CI: 0.932 approximately 2.298); the risk of CWP in those with FAS-670AG genotype was higher than those with FAS-670GG genotype (P = 0.098, 95% CI: 0.928 approximately 2.404) the risks of CWP in those with FASL-844TT genotype and FASL-844TC genotype were respectivel