Clinicopathologic features of retinoblastoma and expression of VEGF and Ki-67 after comprehensive treatment

• Published in: Chung-hua yen k'o tsa chih Vol. 47; no. 2; p. 134
• Main Authors: Xue, Kang, Qian, Jiang, Bi, Ying-Wen, Yao, Yi-Qun, Yuan, Yi-Fei, DA, Cui-di
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2011
• Subjects: Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Ki-67 Antigen - metabolism; Male; Neoplasm Staging; Retinal Neoplasms - metabolism; Retinal Neoplasms - pathology; Retinal Neoplasms - therapy; Retinoblastoma - metabolism; Retinoblastoma - pathology; Retinoblastoma - therapy; Retrospective Studies; Vascular Endothelial Growth Factor A - metabolism
• ISSN: 0412-4081
• DOI: 10.3760/cma.j.issn.04124081.2011.02.008

To investigate the clinic pathologic features of retinoblastoma (RB) after comprehensive treatment, and study the expression of vascular endothelial growth factor (VEGF) in retinoblastoma treated with chemotherapy prior to enucleation. Retrospective analysis was performed on retinoblastoma specimens obtained consecutively between 2006 and 2008 by enucleation, and patients' clinical information and clinic pathologic features were also collected. Immunohistochemical staining and real-time PCR were performed for the expression of VEGF. Immunohistochemical staining was also performed for Ki-67. Among the 9 chemotherapy-treated cases, six belonged to group D and three to group E of IIRC. The reasons for enucleation included extensive vitreous seeds, RB recurrence, extensive subretinal fluid/seeds, vitreous hemorrhage and total tractional detachment of the retina. During the comprehensive treatment, the main tumors regressed in all eyes. The main tumors showed a mean decrease of 43.7% in the largest basal diameter