Study on the efficacy of hepatitis B virus vaccination and its influencing factors among children in rural area of Jiangsu province

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 28; no. 4; p. 322
• Main Authors: Zhai, Xiang-jun, Wang, Hua, Zhu, Feng-cai, Yu, Jia-xi, Chen, Yin-zhong, Qiu, Xiang-peng, Gu, Shan-Kun, Liu, She-lan, Qin, Li-ming, Liang, Zheng-lun, Zhuang, Hui
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2007
• Subjects: Adult; Child; Child, Preschool; China - epidemiology; Female; Hepatitis B - epidemiology; Hepatitis B - immunology; Hepatitis B - prevention & control; Hepatitis B - transmission; Hepatitis B Surface Antigens - blood; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; Humans; Infant; Infectious Disease Transmission, Vertical; Pregnancy; Rural Population; China
• ISSN: 0254-6450

To evaluate the efficacy of hepatitis B viruse (HBV) vaccination and its influencing factors among children in rural area of Jiangsu province. Twenty-five hundred and twenty-two children born after 1998 in rural area were selected as the study population using multistage cluster sampling method. HBsAg and anti-HBs were detected by enzyme linked immunoassay (ELISA) and radio-immunoassay (RIA), respectively. Anti-HBs negative children were boosted using different hepatitis B vaccines and the efficacy was compared. Factors causing HBV infection in HBsAg positive children were also investigated. HBsAg positive rates in 1-7 year olds were 0.28%-1.28%, and the anti-HBs positive rates decreased from 76.7% to 45.5%. The HBsAg positive rate in children not timely vaccinated was significantly higher than those with HBV vaccine injection within 24 hours after birth (1.4% vs. 0.5%, P = 0.031). More than 90% of the anti-HBs negative children had protective level of anti-HBs after boosted with HBV vaccine. HBsAg positive r