The morphological and immunohistochemical features and malignancy potential of a hyalinizing trabecular tumor of the thyroid

• Published in: Arkhiv patologii Vol. 71; no. 6; p. 36
• Main Authors: Abrosimov, A Iu, Dvinskikh, N Iu, Makanin, M A, mal'kov, P G, Grinevich, V N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.2009
• Subjects: Adult; Carcinoma, Medullary - blood supply; Carcinoma, Medullary - metabolism; Carcinoma, Medullary - pathology; Carcinoma, Papillary - blood supply; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - pathology; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins - metabolism; Retrospective Studies; Thyroid Neoplasms - blood supply; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology
• ISSN: 0004-1955

The paper considers the morphological features of a rare hyalinizing trabecular tumor of the thyroid, which is of follicular cell origin. The signs of invasive tumor growth into to the intrinsic capsule and its blood vessels were observed in 2 of 7 cases. There was a positive immunohistochemical reaction of tumor cells with antibodies to thyroglobulin and neuron-specific enolase and a negative one to calcitonin, galectin 3, cytokeratin 19, and HBME-1. The differential diagnosis of a tumor and papillary and medullary carcinomas of the thyroid, as well as its malignancy potential are discussed in the paper.