Utility of CPT-11 as salvage chemotherapy for progressive or recurrent breast cancer patients with multiple drug resistance

Salvage chemotherapy is necessary to maintain QOL among progressive or recurrent breast cancer patients with multiple drug resistance. We reported seven Japanese patients who received CPT-11 as salvage chemotherapy. Performance statuses of all patients were 1 or 2, and all patients were managed by a...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 37; no. 6; p. 1095
Main Authors Fushimi, Koya, Nakano, Shigeharu, Kumagai, Kyoya, Yamamoto, Naohito
Format Journal Article
LanguageJapanese
Published Japan 01.06.2010
Subjects
Adult
Aged
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Camptothecin - adverse effects
Camptothecin - analogs & derivatives
Camptothecin - therapeutic use
Diarrhea - chemically induced
Disease Progression
Drug Resistance, Multiple
Humans
Middle Aged
Neutropenia - chemically induced
Recurrence
Salvage Therapy
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Summary:Salvage chemotherapy is necessary to maintain QOL among progressive or recurrent breast cancer patients with multiple drug resistance. We reported seven Japanese patients who received CPT-11 as salvage chemotherapy. Performance statuses of all patients were 1 or 2, and all patients were managed by ambulatory treatment. CPT-11 was administered at a dose of 80-100mg/m2 weekly on day 1 for 3 consecutive weeks, followed by a 2-week rest period. One patient had a partial response and CPT-11 was administered for 68 weeks. Two patients had grade 3 neutropenia. Grade 3 diarrhea was not observed. CPT-11 is a very useful choice as salvage chemotherapy for breast cancer patients with recurrence or local progression.
ISSN:0385-0684