Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.

• Published in: Zhōnghuá xuèyèxué zázhì Vol. 30; no. 11; p. 741
• Main Authors: Wu, Xiao-Jin, He, Jun, Wu, De-Pei, Sun, Ai-Ning, Bao, Xiao-Jing, Qiu, Qiao-Cheng, Yuan, Xiao-Ni, Li, Wei-Yang, Chang, Hui-Rong, Han, Yue, Ma, Xiao, Zhu, Zi-Ling, Xu, Yang, Feng, Yu-Feng, Dai, Li-Jun
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2009
• Subjects: Genotype; Haplotypes; Hematopoietic Stem Cell Transplantation; HLA-C Antigens - genetics; Humans; Receptors, KIR - genetics
• ISSN: 0253-2727

To explore the relationship between CMV reactivation and KIR haplotype or HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation (HSCT). From January 2003 to December 2008 the HLA-Cw/KIR genotype of 48 patient-donor pairs were determined by polymerase chain reaction with sequence specific primers (PCR-SSP) and sequence specific nucleotide (PCR-SSOP). Posttransplant CMV reactivation was performed by immune histochemically assay. Of 48 patients, 15 were transplanted from unrelated donors with an antigen mismatch for HLA Cw and 33 patient-donor pairs were matched for HLA-Cw. The CMV reaction rate was 66.7% for HLA-Cw mismatch group and 48.5% for HLA-Cw match group (chi(2) = 1.39, P = 0.2375). Thirty-seven donor-patients pairs belonged to group C1 and 11 to group C2, and CMV reaction rate was 64.9% in group C1 and 18.2% in group C2 (chi(2) = 18.13, P < 0.0001). Twenty-six patients received graft from KIR haplotype A (group A donor) and 22 from KIR haplotype B donors (group B don