A case of secondary pulmonary cryptococcosis presenting with multiple cystic shadows

• Published in: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society Vol. 49; no. 4; p. 315
• Main Authors: Takata, Seiichi, Yoshioka, Yuichi, Naito, Hiromichi, Kozuma, Kazuo, Kinuwaki, Etsuo
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.04.2011
• Subjects: Aged, 80 and over; Arthritis, Rheumatoid - complications; Cryptococcosis - diagnostic imaging; Diabetes Complications; Female; Humans; Lung Diseases, Fungal - diagnostic imaging; Tomography, X-Ray Computed
• ISSN: 1343-3490

An 80-year-old woman with a history of rheumatoid arthritis and steroid diabetes had been given a diagnosis of multiple bilateral pulmonary cystic lesions 16 months previously, and these lesions were observed to gradually increase on follow-up. She presented with a fever of 38 degrees C, cough, and sputum for 2 weeks, and the pulmonary cystic lesions had enlarged, and therefore she was admitted. A chest X-ray film revealed multiple cystic lesions 4 cm in greatest dimension in both the left upper and middle lung fields, and chest computed tomography (CT) scans revealed that the lesions of the left S1+2 had niveau formation with a partially thickened wall. However, the lesions in the left S4 and S5 areas and the right S8 area had thin, smooth walls. Transbronchial lung biopsy of the left S4 lesion yielded granuloma formation and yeast-like fungus bodies within multinucleated giant cells, while bronchial lavage fluid culture showed cryptococcus neoformans. It is known that pulmonary cryptococcosis presents various images and histopathologic findings, according to the immune interactions between the fungus body and the host. We report a rare case that presented with multiple cryptococcal cystic lesions.